The concert hall is expected to be fully restored by then, following extensive damage, estimated at about $40 million, caused by a May flood.
Music Director Giancarlo Guerrero will lead the orchestra in the concert, which is to begin at 9 p.m. Dec. 31.
"We are beyond thrilled about returning to Schermerhorn Symphony Center," Nashville Symphony President and Chief Executive Officer Alan Valentine said in a statement. "This is a truly momentous occasion, and I can't think of a better way to celebrate than by having Itzhak join the orchestra. We are deeply honored that he has decided to spend his New Year's Eve with us."