The couple have been married nearly 24 years and are the parents of 10-year-old twin boys.
E! News said Wilson cited irreconcilable differences as her reason for filing for divorce last week in Los Angeles Superior Court.
Wilson said in her paperwork she and Crowe separated June 15, 2008, E! noted.
Crowe's films include "Vanilla Sky," "Almost Famous," "Jerry Maguire" and "Say Anything."