The BBC said Frusciante beat out former Guns n' Roses guitarist Slash, who finished No. 2; Matt Bellamy of Muse; Johnny Marr of The Smiths and Rage Against the Machine's Tom Morello for the top spot.
About 30,000 listeners voted in the BBC 6 Music's Axe Factor poll conducted online, the BBC said.
Benedict Cumberbatch's dramatic reading of R. Kelly lyrics is just what you need
Exploding whale video goes viral on Internet