The event is to take place Nov. 22 at the NOKIA Theatre L.A. LIVE in Los Angeles. It is to air live on ABC.
Additional performers and presenters are expected to be announced in the coming weeks, the network said.
"We are excited to have Eminem and Lady Gaga on the show this year," American Music Awards producer Larry Klein said in a statement. "You can never predict what surprises they have lined up, so these are sure to be unique and memorable performances."
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