The group's songs "Oye Como Va," "Everything's Coming Our Way" and "Evil Ways," as well as others, will be heard in "Dead Heat," the Nov. 8 installment of the show. In it, the team investigates after the body of an accomplished 45-year-old jockey who disappeared in 1986 is found in a mass horses' grave.
Jacob Vargas from "Traffic" and "Bobby" is to guest star as the slain jockey's apprentice.
"We're delighted to feature the music of Santana throughout this episode, which offers a behind-the-scenes glimpse into the high-stakes world of thoroughbred horseracing as the team investigates the mid-'80s murder of a successful Mexican-born jockey," series executive producer Jennifer Johnson said in a statement.
"Santana's music has that hypnotic blend of the ethereal and explosive that captures the excitement and beauty of the sport of kings -- and still reflects the internal conflict of an athlete coming to terms with the sport's unforgiving nature and decadence," said series executive producer Greg Plageman.
Past single-artist episodes of "Cold Case" featured the music of Ray Charles, John Lennon, Frank Sinatra, Nirvana, Johnny Cash, John Mellencamp, Bruce Springsteen, Tim McGraw, U2 and Bob Dylan. The music of Pearl Jam rocked throughout the two-part seventh season finale of the series.