The 38-year-old actress made the comparison during an interview with Sky News Friday.
"I don't [Google myself]," she says of her celebrity. "That's my saving grace. I think it's when you start living in that world and doing that, that you start feeling raped."
When asked if she meant to make such a strong comparison, she responds, "Well, when it comes to your son and your private life. Maybe it's just me."
"#CharlizeTheron your timing is shocking given the brutal rape and murders in India. Get real!" one person writes.
"#CharlizeTheron is a complete moron..." another person adds. "Maybe a private life being intruded on is awful... But comparing it to rape? #get a grip."