Pre-production is to begin this winter in Germany.
Director Perez co-wrote the film's screenplay with Achim von Borries.
Based on a true story, Hans Fallada's novel was written shortly after World War II and describes a city paralyzed by fear.
"Otto and Anna Quangel are an ordinary couple living in a shabby apartment block in Berlin trying, like everyone else, to stay out of trouble under Nazi rule. But when their only child is killed fighting at the front, their loss propels them into an extraordinary act of resistance," a synopsis said. "They start to drop anonymous postcards all over the city attacking Hitler and his regime. If caught, it means certain execution. Soon their campaign comes to the attention of the Gestapo inspector, Escherich, and a murderous game of cat-and-mouse begins. But the game serves only to strengthen Otto and Anna's sense of purpose, and slowly their drab lives and marriage are transformed as they unite in their quiet, but profound rebellion."
"We are thrilled that Emma, Daniel, and Mark were immediately as fascinated as we are of this most suspenseful love story of all times. And it's a true story -- best-selling 60 years after its first publication," film producer Stefan Arndt said in a statement.
"It's a delight and a privilege to be reuniting once again with some of my old partners on the film version of this recently re-discovered, 20th-century masterpiece. It couldn't be more worthy of a film adaption and we're looking forward to bringing it to audiences around the globe," said Alison Thompson, whose Sunray Films is selling the movie in Cannes.
Emma Thompson most recently starred in Saving Mr. Banks, while Bruhl is known for his work in the film Rush and Rylance is a current Tony Award nominee for Richard III.