Cooper is best known for his Academy Award-nominated performance in the film "Silver Linings Playbook" and the "Hangover" comedy trilogy.
"Guardians" will also feature voice performances by Chris Pratt, Zoe Saldana and Dave Bautista.
Directed by James Gunn, the movie opens Aug. 1, 2014.
Ohio crash that killed two caught on camera [VIDEO]
Twerking Brooklyn burglar 'dropped it like it was hot' prior to theft