"Marisa brings an intelligence, warmth, and graceful humor to everything she does," Sachs said in a statement Wednesday. "From our first meeting, it was clear that in her hands, the role of Kate would resonate deeply with audiences. She elevates all of us involved to be at our very best."
The character of Kate is described as "a novelist married to Lithgow's nephew, who lets his uncle move in with them after he's forced to sell his small apartment."
Tomei's film credits include "Parental Guidance," "The Ides of March," "Crazy, Stupid, Love," "The Wrestler," "In the Bedroom," "My Cousin Vinny" and "Untamed Heart."