The R-rated comedy casts Sudeikis as a low-level marijuana dealer and Aniston as a stripper, who team up to smuggle drugs out of Mexico into the United States for a huge payday. The pair enlist the help of two lonely, neglected teens -- played by Emma Roberts and Will Poulter -- to help create the illusion of a wholesome family traveling on a vacation in a recreational vehicle.
Asked if she as an actress -- who frequently becomes close to her co-stars in the process of creating illusions for films -- could relate to the way the "Millers" characters developed real affection for each other while pretending to be a family, Aniston told United Press International in New York recently: "I don't think it happens where it is an illusion.
"I think we actually become a family [on film sets]," she said. "You spend three, four months of your life. Every day, all day, sometimes way too long and you just have each other."
"It's the reality-show model," Sudeikis added. "Put people in the same town in the middle of North Carolina for four months. Give them a job. We're not working in a T-shirt factory. We're making a movie and you end up loving each other and liking each other and hating each other and getting annoyed with each other and everything the movie goes through. So, it's not so much like the process of making the movie and faking it as an actor. It's probably more being used to having done other movies and get that across, just the familial aspect that occurs when you hang out with people for so long."
"They basically find their family out of this crazy situation," Aniston said of the characters in the film.
"They kind of find the soft spot in each other and find partnership, which is what everyone's looking for, companionship," she said. "That's sort of what was fun about it. The attitude we kind of have toward each other in the beginning. I can't stand him and I don't know the kids."
Co-starring Ed Helms, Nick Offerman, Molly Quinn and Kathryn Hahn, "We're the Millers" opens nationwide Aug. 7.
2014: The Year in Music [PHOTOS]