Foresight Unlimited in association with Castle Rock announced Wednesday production had officially begun.
The film marks the first time Douglas and Keaton have appeared on-screen together. Reiner previously collaborated with Douglas on the hit 1995 film "The American President."
Joining the cast in a pivotal supporting role is Sterling Jerins, a young actress who will soon be seen in the movies "The Conjuring" and "World War Z."
"Oren is a self-centered real-estate agent who couldn't care less about anyone else," said a synopsis of "And So It Goes..."
"But Oren's life is turned upside down when his estranged son suddenly drops off a granddaughter he never knew. Now, with the help of his determined and loveable neighbor, Leah, Oren stubbornly learns to care, and unexpectedly, to fall in love again."
The cast also includes legendary crooner Frankie Valli as well as Scott Shepherd and Frances Sternhagen.