The "Salt," "Wanted," "Girl Interrupted" and "Lara Croft" star made the comments in an interview this week with Britain's Channel 4 News.
"I think I'm going to have to give up the acting as the kids hit the teenage years, anyway, too much to manage at home," the 37-year-old Oscar winner said.
"I have enjoyed being an actress," Jolie said. "I am so grateful to the job and I have had great experiences and I have even been able to tell stories and be a part of stories that mattered and I have done things for fun, but ... I will do some films and I am so fortunate to have the job, it's a really lucky profession to be a part of and I enjoy it. ... But if it went away tomorrow I would be very happy to be home with the children. I wake up in the morning as a mum and I turn on the news like everybody else and I see what's happening and I want to be part of the world in a positive way."