The movie offers "an in-depth look at the high-stakes world of drug dealing and drug enforcement by blending authentic reportage with pop-culture references," a synopsis said.
It debuted last Friday night at the Toronto International Film Festival.
Directed by Matthew Cooke, the film reunites producers Bert Marcus of Bert Marcus Productions and Adrian Grenier, the team that created the breakout hit "Teenage Paparazzo."
Tribeca Film said it plans a 2013 theatrical release for the film day and date with on-demand platforms.
The documentary features interviews with government and law-enforcement officials, as well as rapper 50 Cent, "The Wire" producer David Simon, columnist Arianna Huffington, actor Woody Harrelson, hip-hop artist Eminem and actress Susan Sarandon.
"This is a work that resonates with truth, anger and insight by an extremely talented filmmaker," Geoff Gilmore, chief creative officer of Tribeca Enterprises, said in a statement. "From politics to the police and drug dealers to drug users, the scope of Matthew Cooke's examination of these illicit networks is extraordinary."