"I just cast Charlie Sheen in #machetekills as the President of the United States! Who better? More soon..." Rodriguez said via Twitter.
Sheen later re-tweeted the post about his role in the sequel to the 2010 movie "Machete."
The cast will include original star Danny Trejo, as well as Mel Gibson, who is new to the franchise.
Sheen, who has long battled addictions to drugs and alcohol, was fired from his CBS sitcom "Two and a Half Men" last year because of his drug use and related erratic behavior. He is now the star of the new FX comedy series "Anger Management."
His father, Martin Sheen, played a beloved president on the political drama "The West Wing."