The Oct. 20 event is a biannual benefit for the Barbara Davis Center for Childhood Diabetes, a care and research center for type 1 diabetes.
Clooney will be presented with the Brass Ring Award for his "outstanding artistic achievements and unprecedented humanitarian undertakings," organizers said.
Aretha Franklin and Kenny "Babyface" Edmonds have been booked to perform at the event.
Notable deaths of 2014 [PHOTOS]
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