The film stars Robert Downey Jr. and an ensemble company. Box Office Mojo reports the record-breaking film has reached $1 billion in receipts worldwide.
"Battleship" was a distant No. 2, even with a healthy $25.3 million in receipts.
All studio estimates of gross U.S. box office receipts are via Box Office Mojo.
"The Dictator" was third with more than $17.41 million; "Dark Shadows" fourth with $12.77 million; "What to Expect When You're Expecting" fifth with $10.5 million; "The Best Exotic Marigold Hotel" sixth with $3.25 million; "The Hunger Games" seventh with $3 million; "Think Like a Man" eighth with $2.7 million; "The Lucky One" ninth with more than $1.76 million.
"The Pirates! Band of Misfits" was 10th with $1.45 million.
Astronomers offer more expansive view of universe
LGBT community has 'bullied the American people': Bachmann