The prize presentation took place Saturday at UCLA's Royce Hall. Actor and comedian Patton Oswalt served as host of the event.
Newcomer Minkyu Lee's "Adam and Dog" won for Best Short Subject. while "Sea" was selected Best Television Commercial.
"The Simpsons" took the award for Best Animated TV Production and "Insanely Twisted" was declared Best Video Game.
"This was a great evening, with a lot of fun and surprises," ASIFA-Hollywood President Frank Gladstone said in a statement. "Annies went to a huge variety of individuals and studios. This goes directly to ASIFA-Hollywood's vision of celebrating the best in animation across project, studio and geographic boundaries."
Attendees and presenters included June Foray, J.K. Simmons, Judy Greer, Zachary Levi, Peter Baynham, Mace Heufeld, Weird Al Yankovic, Bruce Boxleitner, Ahmed Best, Kathleen Kennedy, Frank Marshall, Jim Cummings, Phil Lamarr, Diedrich Bader, Daran Norris, Tara Strong, Kelly Stables, Dee Bradley Baker, Nika Futterman, Ariel Winter, Logan Grove, James Hong, Brian Posehn, Greg and Evan Spiridellis and Jim Meskimen, Bridgit Mendler, Brittany Snow, Jason Marsden and Joe Letteri.