Frederick's representative confirmed her casting this week.
"The 'M' Word" explores the themes of "menopause, men and menses," a synopsis reveals.
Frederick previously collaborated with Jaglom on "Hollywood Dreams" "Irene in Time," "Queen of the Lot" and the upcoming film adaption of Jaglom's hit play "Just 45 Minutes from Broadway."
Jaglom made his directing debut in 1971 with "A Safe Place," starring Jack Nicholson and Orson Welles. His other films include "Can She Bake a Cherry Pie?," "Babyfever," "Eating" and "Going Shopping."
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