The film's producers described the movie as "an outlandish yet poignant comedy about a pair of battling brothers who attempt to honor their ailing father by taking a troop of boys on a last-ditch camping trip that goes wildly wrong."
Production on the movie began last week with an ensemble that includes Rob Riggle, Maura Tierney and Patrice O'Neal.
The film is being financed by Marc Turtletaub's and Peter Saraf's Big Beach Films. Turtletaub, Saraf and Lisa Muskat are producing, David Gordon Green is executive producing, and Michael Clark and John Hodges will oversee production for Big Beach.
"Todd looks at the world through a different set of lenses than the rest of us, and yet his vision manages to be simultaneously unique and universal," Saraf said in a statement. "I think that's because his humor, while twisted at times, is fundamentally compassionate and truthful. The combination of Todd with this hilariously amazing cast is going to make for an exciting ride, and we're tightening our seat belts."
Rohal's previous films were "The Catechism Cataclysm" and "The Guatemalan Handshake."
Knoxville is the co-creator and star of the "Jackass" franchise. His movie credits include "Men in Black II," "The Dukes of Hazzard" and "The Ringer."
Oswalt is a standup comedian who has appeared in the TV sitcom "King of Queens" and the films "Magnolia," "Man on the Moon" and "Starsky & Hutch."