The "Scream" star and estranged husband of actress Courteney Cox allegedly drove his car into oncoming traffic in Beverly Hills, Calif., and collided with another vehicle while trying to avoid hitting a third car that stopped short, TMZ.com said.
The Beverly Hills Police Department told People.com the drivers were the only occupants of the cars. Both drivers were taken to Cedars-Sinai Medical Center where they were treated for minor to moderate injuries.
The collision was under investigation, People.com said.
Arquette and Cox separated last year. Arquette has since sought treatment for alcohol addiction in rehab and spoken publicly about his hopes of reconciling with his wife.