"Like Crazy," starring Anton Yelchin and Felicity Jones, is about a young couple facing immigration issues.
The film won the dramatic grand jury prize, the festival's top award, as the festival concluded Saturday, The Los Angeles Times said. It was the second award for the film. Jones previously won a special prize for her role in the movie.
The movie will be released by Paramount later this year.
Peter D. Richardson's "How to Die in Oregon" was awarded the grand jury U.S. documentary prize. It is about the first state to legalize physician-assisted suicide.
The audience gave its top U.S. dramatic prize to the Persian-language movie "Circumstance" and named Cindy Meehl's "Buck" as the top U.S. documentary.
In addition to "Like Crazy," three other films won a pair of jury prizes --Paddy Considine's "Tyrannosaur," Mike Cahill's "Another Earth" and Danfung Dennis' documentary, "Hell and Back Again."
Ellen Barkin's wedding-day comedy "Another Happy Day" won the Waldo Salt screenplay award for script by writer-director Sam Levinson, the son of Hollywood filmmaker Barry Levinson.