The ex-commander-in-chief filmed his spot during the weekend in Bangkok while he was in town to deliver a real-life speech on clean energy.
Clinton plays himself in the follow-up to the 2009 blockbuster "The Hangover," People.com said.
Directed by Todd Philips, both films star Bradley Cooper, Ed Helms, Zach Galifianakis and Justin Bartha.
Rosie O'Donnell unveils nearly 50-pound weight loss
Members of Congress to keep receiving porn magazine