The event is to take place Sunday at the Los Angeles museum, it was announced Tuesday by museum officials.
Slated to perform at the ceremony are this season's "America's Got Talent" grand prize winner Michael Grimm and "American Idol" winner Taylor Hicks.
"George Lopez is an incredibly talented comedian and actor and we are honored that he is able to join us as MC on Sunday as we honor the legendary Clint Eastwood," Rabbi Marvin Hier, founding director of the MOTIFF and founder and dean of the Simon Wiesenthal Center and the Museum of Tolerance.
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