The "Milk" and "Mystic River" star will be given the Hollywood Humanitarian Award at the festival's Hollywood Awards gala ceremony Oct. 25 at the Beverly Hilton Hotel in Beverly Hills, Calif.
He is being recognized "for his incredible selfless and dedicated humanitarian efforts in saving lives, as well as bringing relief to the human suffering in Haiti," organizers said.
The announcement was made Wednesday by Carlos de Abreu, the festival's founder and executive director.
"It is an honor to recognize the inspiring humanitarian efforts that Sean Penn and his J/P Haitian Relief Organization have been providing to the great people of Haiti," de Abreu said in a statement.
2014: The Year in Music [PHOTOS]