Its stars, Robert Pattinson and Kristen Stewart, won for best male performance and best female performance and Pattinson took home a golden popcorn statuette for the new category of "Global Superstar" at the awards ceremony Sunday, MTV said in a news release.
Stewart's best actress award was her second in two years for her work in the film series about a teenager who falls in love with a vampire (Pattinson).
"The Hangover," a surprise hit of 2009, won two awards -- one for Zach Galifianakis for best comedic performance and one for Ken Jeong for best "WTF" moment. Jeong played an over-the-top bad guy in the story of a bachelor party gone wrong in Las Vegas.
Anna Kendrick was honored as best breakout star for her performance in "Up in the Air" and Tom Felton was named best villain for his performance as Draco Malfoy in "Harry Potter and the Half-Blood Prince."
Oscar-winning actress Sandra Bullock received the MTV Generation Award for her overall career. She was also nominated for best kiss, with Ryan Reynolds in "The Proposal," and Bullock planted a kiss on Reynolds' wife, actress Scarlett Johansson, so Johansson wouldn't feel left out, MTV said.