The Oscar-winning stage and film star will be seen discussing the recent deaths of her daughter, Natasha Richardson; sister, Lynn Redgrave; and brother, Corin Redgrave on Friday's edition of the show.
The interview is being billed by ABC as Vanessa Redgrave's "first and only interview" since Lynn Redgrave's death earlier this month.
Vanessa Redgrave also talks about her relationship with her husband, actor Franco Nero, opposite whom she stars in the new film, "Letters to Juliet," the network said.
'SNL': 'Anchorman 2' cast, One Direction sing 'Afternoon Delight' [VIDEO]
Trader Joe's: Car crashes into Long Island store, injuring 11