Alley is best known for her work on TV's "Cheers," "Veronica's Closet" and "Fat Actress." Her film credits include the "Look Who's Talking" movies, "Star Trek II" and "Sibling Rivalry."
Set to premiere March 21, "Big Life" will "chronicle the extraordinary life of Golden Globe and two-time Emmy winner Kirstie Alley from her journey with her weight-loss program to her life as a single mother trying to raise two normal teenagers in the Hollywood spotlight," A&E said in a news release.
"This show has been cathartic for me ... shown me who I really am ... again," added Alley. "And it's really freaking funny."