The Expendables 3 actor, 54, was photographed getting cozy with several blondes at restaurant L'Opera in the French beach town. He was later seen leaving with a woman in a jumpsuit.
The sighting of Banderas enjoying single life comes weeks after his estranged wife was seen covering her "Antonio" tattoo with a bandage that reads "Mel." Griffith has been covering her famous ink in different ways -- and is believed to be removing it permanently -- since filing for divorce from the Spanish actor in June.
The divorce will be the second for both actors. The former couple have one daughter, Stella, who turns 18 in September.
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Polly Bergen, Emmy Award-winning actress, dies