Upon learning about the speculation, the Playboy mogul, 88, reportedly told Wilkinson to "come to the Playboy Mansion any time," an insider told Us Weekly.
Hefner's calls come on the heels of rumors that Baskett cheated on the former Playmate with transgender YouTube star Ava Sabrina London. After laughing off the rumors when reports about the affair first surfaced in 2013, Wilkinson allegedly "flipped out" in June after finding an unexplained charge on her husband's credit card.
"[Hefner has] been supportive and hates that Kendra is going through this," the insider added.
Wilkinson and Hefner dated for four years until 2008, the model went on to marry Baskett in 2009 and has two children with him: Hank IV, 4, and 1-month old daughter, Alijah.