The Kennedy Center announced Wednesday that it had chosen the 64-year-old comedian as this year's recipient of the 2014 Mark Twain Prize for American Humor.
The award ceremony, held October 19 at the Kennedy Center Concert Hall, will also air November 22 on PBS.
"What an honor!" Leno said in a statement. "I'm a big fan of Mark Twain's. In fact, 'A Tale of Two Cities' is one of my favorite books!"