The film also garnered Vardalos an Oscar nomination for bestscreen play and inspired a short-lived sitcom on CBS.
"Now that I'm experiencing motherhood, I'm ready to write the next chapter of my family story," Vardalos said in a statement. "Of course a few jaded folks in the press corps will claim I ran out of money or just want to kiss John Corbett again. One of these things is true."
Vardalos will reprise her role as a first-generation Greek-American woman, with John Corbett also returning. There's still no word on Joey Fatone.
According to Variety, the sequel plot will involve a "family secret" and a "bigger, fatter wedding."
Celebrity Families of 2014 [PHOTOS]