The Russian model, 28, posed in a structured white dress and minimum makeup for the cover as Ronaldo stood behind her with his hands on his hips revealing part of his chest and just a peek at his inner thigh.
The couple was photographed by fashion photographer Mario Testino for the "Amor & Fútbol," ("Love and Soccer") feature on the glossy's June issue.
"Sharing this cover with Irina means a lot," the Real Madrid player told Vogue. "Irina is the most beautiful woman in the world and working with her has been, besides a surprise, something special. That was the first time we did something together and I've enjoyed it."
Vogue Spain's June issue is out now.