The 28-year-old television personality gave birth to a daughter via c-section at the Cedars-Sinai in Los Angeles, according to TMZ.
Wilkinson revealed she was on her way to the hospital late Thursday night via Twitter.
"This is it guys. It's time. Love you all n tweet to ya again when I can. Xoxoxo," she wrote to her 2.46 million followers.
Wilkinson and Baskett married in June 2009 at the Playboy mansion. The couple welcomed their first child, a boy named Hank Baskett IV, on December 11, 2009.