Milano posted a video announcement on her website to share the big news.
"I'm in my Mistresses dressing room and I wanted to share with you guys that I am expecting a little sweet baby girl," she said. "David, Milo and I could not be happier. Truly, we could not be happier. So exciting!"
Milano announced her pregnancy in March on her personal website.
This is her second child with husband David Bugliari. They have a 2-year-old son named Milo.
2014: The Year in Fashion [PHOTOS]