The Fox film, starring Diaz, Mann and model Kate Upton as women who discover that they're in relationships with the same man, pulled in $24.7 million over the weekend. Captain America: The Winter Soldier, which spent three weeks in the No. 1 spot, dropped to second place with $16 million.
Women made up 75 percent of the The Other Woman's audience and gave the film a respectable B+ CinemaScore, despite mostly negative critical reviews.
“I think the combination of the three leads was a big draw, but Cameron has a great track record with comedies,” Fox exec Spencer Klein told the LA Times. “Once again, you see the power of a female-driven comedy.”
Christian film Heaven Is for Real came in at No. 3, while Rio 2 earned $13.7 million for fourth place.
Paul Walker's penultimate film, Brick Mansions, rounded out the top five with a modest $9.6 million.