"The Lindsay show is a tragedy - on every level - I hope one day she gets sober for real and watches these episodes - n sees what we all do," O'Donnell wrote Tuesday.
Oprah Winfrey scored Lohan's first interview out of rehab last year, and signed the 27-year-old to a reality series for the OWN network. It hasn't performed well in the ratings, but has put Lohan back in the spotlight.
"I have a really strong bond with [Oprah] where I can call her for advice and she has become someone I can learn from in life," the actress told Fallon last month.
Despite O'Donnell's objections, Oprah told Letterman last week that Lohan has been doing just fine.
"I think she's doing really OK," Winfrey said. "To have cameras following you around for every phase of your life, and you are trying to pull your life together, I think that's a really difficult thing. So, yeah, we're really pleased she's making some progress."
[H/T NY Daily News]