The E! News host and Giuliana & Bill reality star appeared on the show for a special Breast Cancer Awareness episode. Rancic is a breast cancer survivor herself, and underwent a double mastectomy at the end of 2011 after she was diagnosed with the disease earlier that year.
The Price is Right host Drew Carey gave Rancic a warm welcome before she served as a model for the episode's prizes.
"It's pretty incredible seeing all these survivors winning all these fabulous prizes on The Price is Right," Rancic said of her appearance. "The fact that I'm a part of it is really cool."
The sixth season of Rancic's reality show, Giuliana & Bill, will debut at 8 p.m. ET April 1 on E!