The 55-year-old singer will perform 22 shows in the United Kingdom for her Before the Dawn tour starting August 26.
Bush's last live concert was in 1979. The performance was part of the only tour the musician has done to date.
"By the end I felt a terrific need to retreat as a person," she later recalled. "I felt that my sexuality, which in a way I hadn't really had a chance to explore myself, was being given to the world in a way I found impersonal."
The singer also said at the time that the tour "was absolutely exhausting," and she didn't know how touring "would work with how my life is now."
Fans have many theories about Bush's reluctance to tour. Some believe perfectionism makes her unwilling to appear on stage in the public eye. Others point to the death of her lighting director, Bill Duffield, during an accident at her April 2, 1979 concert.
Bush has performed since during appearances at other people's events, but never as part of her own show. She released her last album, 50 Words for Snow, in 2011.
"I'm completely overwhelmed by the response to the shows," Bush said after tickets to Before the Dawn sold out after 15 minutes. "Thank you so much to everyone. Looking forward to seeing you all later this year."