The 38-year-old actress was in a call with the Kyle & Jackie O Show when she was asked to partake in the kiss-and-tell game, in which the co-hosts would name celebrities and Reid had to answer whether she had kissed them or not.
When the name Tom Brady came up, Reid responded, "Have kissed," adding, "Yes, he's pretty good looking."
The New England Patriots quarterback and Reid were rumored to have dated for a brief time back in 2002. He eventually went on to marry Brazilian supermodel Gisele Bündchen, with whom he has three children.
During the game Reid also denied having kissed her American Pie co-star Jason Biggs.
"No way," the actress said when Biggs' name was mentioned.
Reid will next star in the upcoming TV movie Sharknado 2: The Second One.