Loughlin, 49, starred as Stamos's crush turned girlfriend turned wife during Full House's eight-year run and according to the actress the two never got together in real life because of timing.
"That was very nice of him to say that," Loughlin said of Stamos' remarks.
"I was married at the time I was doing the show to my first husband," she explained. "Right as I was getting divorced, he met Rebecca."
Loughlin was married to Michael Burns from 1989 to 1996 and is currently married to fashion designer Mossimo Giannulli. The couple has two daughters together, Isabella (born in 1998) and Olivia (born in 1999).
You can check out a clip of Loughlin's interview here.