He bought the 1924 Spanish-style house in 2009 for $1.775 million, though since then he's spent much of his time in Vancouver, Canada, where filming of Supernatural takes place.
The 3,818-square-foot house features four bedrooms, five bathrooms, a library, family room, vaulted beam ceilings and stained glass.
Padalecki has starred in the CW's Supernatural as Sam Winchester since 2005, and the show was recently renewed for a 10th season. Before that he spent five years on Gilmore Girls.
[Los Angeles Times]