The sneak peek, posted to the network's website Tuesday, finds Lohan dealing with her new life as a recovering alcoholic.
"There's nothing left in having a drink for me," the Mean Girls star says at the beginning of the clip. "What's left in that feeling? Nothing. There's no party that I haven't gone to, there's no person I haven't hung out with. There's no situation I haven't been exposed to."
The series will deal with the actress's stressful life under the eyes of the paparazzi, and follow her sixth attempt at sobriety. Lohan's parents Michael Lohan and Dina Lohan will also appear on the show.
The series premiere of Lindsay airs Sunday, March 9, at 10/9c on OWN.