The sale is scheduled to take place Nov. 2 at the polo grounds in Santa Barbara, the New York Daily News reported.
All of the items that will be up for bid at the event have been listed under "The Oprah Winfrey Collection" on KaminskiAuctions.com.
Among the items for sale are a Victorian-style doll carriage that will start at $100 and an 18th-century Louis XVI Leonard Boudin bureau that has been valued around $50,000. Winfrey's personal memorabilia, such as a picture of her and NBA star Michael Jordan and a 68-inch autographed print of her 1998 Vogue magazine cover, is also up for grabs.
Winfrey hinted at the sale in the March issue of her "O" magazine, saying she planned to remodel her home in Montecito to reflect her true self.
"The gilded mirrors, marble urns, the lavish carpets and sherbet palette -- it was all very grand, but it wasn't very true to myself," she wrote.