The rapper, whose real name is Jayceon Taylor, has already channeled about $80,000 into the fund, launched three weeks ago, People magazine reported Friday.
"It's a hand-to-hand project," The Game said. "If I see someone who looks like they could use it and my heart tells me I should contribute to their struggles, I'll give them something. The direction comes from within."
The rapper said celebrities have already been calling him looking to contribute as well.
"So many people want to be part of it already. It's crazy. I had no idea I'd set something like this off," he said.
"When people tell me what I'm doing is great, I'm like, 'Are you talking to me? I'm The Game! I'm dangerous!' But doing all of these acts has brought a tremendous amount of positivity to my life. I'm still who I am at the core, but I have a heart," he said.
The Game, along with fellow rapper Drake, each donated $20,000 last week to Anna Angel, an Ohio woman whose five children and boyfriend died in a mobile home fire.