The model said she brushes off any comments from people who don't appreciate her curvy figure.
"The things that they're rejecting are things that I can't change. I can't change my bra size," she says in the interview. "They're natural! I can work out and I can stay healthy and motivated, but I can't change some things," she said.
Upton was named the highest-ranking model on Maxim's just-announced Hot 100, and she was on the cover of the last two Sports Illustrated swimsuit editions in a row.
This was the model's first Vogue cover, People magazine reported Friday.