The Tony- and Emmy Award winner is best known for his work on the TV sitcom "Frasier." He can now be seen in the Broadway stage comedy "Vanya and Sonia and Masha and Spike."
The Drama League Awards luncheon is to be held May 17 at the Marriott Marquis Times Square in Manhattan.
Pop icon Cyndi Lauper and Emmy Award-winning actress Mary Tyler Moore are to present special awards to Tony Award-winning director-choreographer Jerry Mitchell and Tony-, Drama Desk- and Grammy Award-winning actress Bernadette Peters.
The 2013 Drama League Nominations for Distinguished Play, Distinguished Revival of a Play, Distinguished Musical, Distinguished Revival of a Musical and Distinguished Performance will be announced April 23 at Sardi's.
"We are thrilled to have our dear friend David Hyde Pierce hosting the best party on Broadway," Drama League Executive Director Gabriel Shanks said in a statement Monday. "We can't wait to celebrate the best of Broadway and Off-Broadway from this marvelous theater season."