Helmed by director Spike Lee and producer James L. Nederlander, the tour is to begin with a two-night engagement at the Murat Theatre in Indianapolis Feb. 12-13.
Tyson will then bring the tour to at least 36 cities, including Chicago, San Francisco, Los Angeles, Houston and Washington.
"After a successful run at the MGM in Las Vegas and on Broadway at the Longacre Theatre with Spike Lee, I'm excited to take 'Mike Tyson: Undisputed Truth' on tour and share it with my fans across the country," said Tyson in a statement.
"'Undisputed Truth' is my story -- I'm giving my all. I'm proud to take the show nationwide, and it's a privilege to continue working with The Nederlander Organization."