The three-character comedy was written by Matt Murphy and Jim Brochu. It is based on the best-selling book by Dan Anderson and Maggie Berman, which recently was featured in the relationship dramedy "Hope Springs," starring Meryl Streep, Tommy Lee Jones and Steve Carell.
Murphy, who is producing the stage production, said he plans to begin the show's open-ended run early next year.
Dates, theater, director, cast and designers will be announced shortly, he said in a release.
"Some of our best tips were picked up and perfected in New York, so we're thrilled that this hilarious adaptation of our best-selling book will premiere off-Broadway," authors and real-life best friends Anderson and Berman said in a statement. "New York theater is no place for amateurs, where the competition is, ahem, stiff. If the audience has just a fraction of the fun watching the play as we did writing the book, it'll be an utterly orgasmic success."