The revival is being staged on Broadway to coincide with the play's 50th anniversary.
Previews will begin Sept. 27 at the Booth Theatre with opening night Oct. 13, 50 years to the day after the play's original Broadway opening Oct. 13, 1962.
"Directed by Tony Award nominee Pam MacKinnon, the production will feature the original Steppenwolf cast led by Tracy Letts and Amy Morton, the playwright and the star of the Pulitzer and Tony Award-winning smash hit 'August: Osage County,'" said a synopsis released Wednesday. "The two will face off as George and Martha, one of theater's most notoriously dysfunctional couples in Albee's hilarious and provocative masterpiece. They will be joined by Carrie Coon and Madison Dirks as the unwitting young couple invited over to George and Martha's for an unforgettable night of cocktails and crossfire."
Irwin was the third actor to win a best actor Tony as George.
The original production was nominated for six Tony Awards and won five, including best play, best actor for Arthur Hill and best actress for Uta Hagen. Ben Gazzara and Colleen Dewhurst won acting Tony Awards for a 1977 revival.