Penned by Nora and Delia Ephron, the show will play for the last time March 25 after 2 1/2 years and 1,013 performances.
"Being able to share the intimate collection of stories in 'Love, Loss, and What I Wore' with audiences all over the world, and see it find its place in the cultural landscape, has been incredibly fulfilling," Roth said in a statement. "I am very proud of how many women this production has touched -- both on stage and off. We have had 32 rotating casts, and 120 actresses have participated during our New York run. The emotional resonance and personal connection people have to this show has been overwhelming."
Directed by Karen Carpenter and based on the best-selling book by Ilene Beckerman, the play opened at the Westside Theatre Oct. 1, 2009.
"Love, Loss, and What I Wore" is performed by a rotating cast of five actors, who take the stage for four-week cycles.
Among the actresses who have appeared in it are Tichina Arnold, Alexis Bledel, Nikki Blonsky, Kristin Chenoweth, Didi Conn, Maddie Corman, Tyne Daly, Fran Drescher, Haylie Duff, Barbara Feldon, Janeane Garofalo, Melissa Joan Hart, Carol Kane, Minka Kelly, Shirley Knight and Sharon Lawrence.
Also taking turns in the show were Adriane Lenox, Stacy London, Jane Lynch, Marla Maples, AnnaLynne McCord, Anne Meara, Janel Moloney, Rosie O'Donnell, Rhea Perlman, Eve Plumb, Doris Roberts, Sherri Shepherd, Brooke Shields, Jamie-Lynn Sigler, Yeardley Smith, Cobie Smulders, Susan Sullivan, Loretta Swit, Dawn Wells, Rumer Willis, Rita Wilson and Kim Zimmer.